Patients with hepatic or renal dysfunction: It is important to let them know. Alcohol may enhance the sedative and hypotensive effects of diamorphine. Diamorphine may be used in the treatment of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnoea in acute pulmonary oedema. For the dose by subcutaneous infusion see below.

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The analgesic effect lasts approximately three to four hours. Read about diamorphine, how you have it and other important information about taking this painkiller. Prophylactic treatment with phenytoin or carbamazepine should be considered.

Diamorphibe undergoes biotransformation to an active metabolite, morphine glucuronide M6G. The starting dose should be selected according to age, size, symptoms and previous analgesic requirements and administered 4 hourly; the dose being titrated according to the degree of pain.

A nurse changes the pump every 24 to 48 hours. The dose may be increased according to individual needs. Sign Up Log In Cancel. Bowel colic and excessive respiratory secretions Bowel colic and excessive respiratory secretions may be reduced by a subcutaneous injection of hyoscine hydrobromidehyoscine butylbromideor glycopyrronium bromide.


Careful assessment of symptoms and needs of the patient should be undertaken by a multidisciplinary team. A white to off-white, sterile, freeze dried powder of Diamorphine Hydrochloride BP for reconstitution for injection. Metoclopramide hydrochloride has a prokinetic action and is used by mouth for nausea and vomiting associated with gastritis, gastric stasis, and functional bowel obstruction. Phaeochromocytoma endogenous release of histamine may stimulate catecholamine release.


Find out more about central lines. If symptoms persist, they can be given regularly via a continuous infusion device.

Intractable cough Intractable cough may be relieved by moist inhalations or by regular administration of oral morphine. Oxycodone hydrochloride immediate-release preparations can be syrineg for breakthrough pain. If affected patients should not drive or use machines. If non-opioid analgesics alone are not sufficient, then an opioid analgesic alone or in combination with a non-opioid analgesic at an adequate dosage, may be helpful in the control of moderate xiamorphine.

About Cancer generously supported by Dangoor Education since It is important not to become pregnant while having diamorphine.

Drugs with antimuscarinic effects antagonise prokinetic drugs and, if possible, should not be diamorphihe concurrently. Diamorphine has been administered in reduced doses to children with neoplastic disease when it becomes difficult to give treatment orally.

If affected patients should not drive or use machines This medicine can impair cognitive function and can affect a patient’s ability to drive safely. Each patient should be assessed on an individual basis. If breakthrough pain occurs give a subcutaneous preferable or intramuscular injection of diamorphine equivalent to dia,orphine of the total hour subcutaneous infusion dose.

Prescribing in palliative care | Medicines guidance | BNF content published by NICE

A prokinetic antiemetic may be a preferred choice for first-line therapy. Syrnge drugs can usually be administered by mouth to control the symptoms of advanced cancer, the parenteral route may sometimes be necessary. These control pain by blocking pain messages to the brain.


Morphine immediate-release 30mg 4-hourly or modified- release mg hourly is usually adequate for most patients; some patients require morphine immediate- release up to mg 4-hourly or modified-release mg hourlythrougu more is needed. Subcutaneous infusion solution should be monitored regularly both to check for precipitation and discolouration and to ensure that the infusion is running at the correct rate.

Dyspnoea Breathlessness at rest may be relieved by regular oral morphine in carefully titrated doses.

Diamorphine | Cancer in general | Cancer Research UK

Talk to your doctor or nurse before you change your dose. A corticosteroid, such as dexamethasonemay also be helpful if there is bronchospasm or partial obstruction. Back to top Accord-UK Ltd contact details. Healthcare professionals are asked to report any suspected adverse reactions tthrough the Yellow Card Scheme at: